Article 9419

Title of the article

STATE OF THE LIPID PEROXIDATION SYSTEM AFTER CHEMICAL BURNING OF THE ESOPHAGUS WITH ACID AND ALKALI SOLUTIONS IN THE EXPERIMENT 

Authors

Shabrov Aleksandr Valer'evich, Assistant, sub-department of surgery, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia), E-mail: Aleksandr_shabrov@rambler.ru
Klimashevich Aleksandr Vladimirovich, Doctor of medical sciences, professor, sub-department of surgery, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia), E-mail: Klimashevich78@mail.ru
Zyul'kin Grigoriy Aleksandrovich, Candidate of medical sciences, associate professor, sub-department of surgery, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia); head of the surgical unit, Penza Regional Clinical Hospital named after N. N. Burdenko (28, Lermontova street, Penza, Russia), E-mail: Zulkin1968@yandex.ru
Petrushova Ol'ga Petrovna, Candidate of biological sciences, associate professor, sub-department of human physiology, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia), E-mail: Olga-petrushova@rambler.ru
Povorinskaya Natal'ya Olegovna, Student, Medical Institute, Penza State University (40, Krasnaya street, Penza, Russia), E-mail: nat8087069@yandex.ru 

Index UDK

616.32 

DOI

10.21685/2072-3032-2019-4-9 

Abstract

Background. Lipid peroxidation is one of the non-specific mechanisms of response to chemical injury of any localisation. Chemical burns of the esophagus with alkali and acid solutions have differences in the pathogenesis. In this study it was determined the differentiation in the dynamics of restoring balance in the system of prooxidants-antioxidants after chemical damage to the esophagus with various corrosive liquids.
Materials and methods. Experimental animals were selected 30 rabbits of the breed of tire shilla. Modeling of a chemical burn of the esophagus with an acid solution was performed using a 46% solution of acetic acid. An experimental model of a chemical burn of the esophagus with an alkali solution was created using an 18.5% sodium hydroxide solution.
Results. Activation of lipid peroxidation processes registrated from 2 to 5 days, regardless of the nature of the corrosive substance. The restoration of the balance of prooxidants-antioxidants was discovered on the 21st day after the alkali chemical burn and on the 30th after the acid chemical burn. On the 45th day of the experiment there was no peroxide imbalance. The state of the prooxidant – antioxidant system was evaluated on the 5th, 14th, 21st, 30th, 45th days from the beginning of the experiment.
Conclusions. The results of the experiment indicate an imbalance in the system of lipid peroxidation after a chemical burn of the esophagus, regardless of the nature of the corrosive substance. An imbalance in the system of prooxidants-antioxidants was stopped on the 21st day after a alkali chemical injury, which is 9 days earlier than a acid chemical burn. 

Key words

modeling of chemical burn of the esophagus, antioxidants 

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References

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Дата создания: 07.04.2020 13:16
Дата обновления: 13.04.2020 12:57